Benzylpiperazine derivatives. IX. Structure-antiulcer activity studies of 1-(aminocarbonylalkyl)-4-benzylpiperazine derivatives by the adaptive least-squares method.
نویسندگان
چکیده
Quantitative structure—antiulcer activity relationships of 1-(aminocarbonylalkyl)-4-benzylpiperazine derivatives (I) were analyzed by using the adaptive least-squares (ALS) technique. Discriminant functions show that (1) a bulky amide moiety is disadvantageous, (2) a small number of methylene groups between carbonyl and piperazine is favorable, (3) a substituent which has a large B1 value (or B2 value when the substituent is forced to be in the in-plane conformation) with low lipophilicity at the 3 and/or 4 position of the benzyl moiety is favorable for antiulcer activity with low acute toxicity.
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عنوان ژورنال:
- Chemical & pharmaceutical bulletin
دوره 36 10 شماره
صفحات -
تاریخ انتشار 1988